Interim long-term follow-up data show AMG 531 increases platelets in patients with ITP
The results suggest that weekly administration of AMG 531 Results in a persistent platelet response. Amgen (Nasdaq: AMGN), the global biotechnology company, announced the preliminary results of an open study shows that long-term use was (up to 48 weeks) of its experimental therapy, AMG 531 was generally well tolerated and stimulated platelet production in patients with immune thrombocytopenic purpura (ITP). A total of 85 percent of patients scored in the study (29 of 34) a platelet response than doubling the number keypad and at least 50,000 platelets per microliter of blood defined.The data were presented in an oral presentation at the American Society of Hematology (ASH) Annual Meeting and Exhibition 47 E.ITP is characterized by a defective immune system that recognizes
the pads of the body as foreign and destroys them, potentially resulting in dangerously low platelet counts (less than 30,000 platelets per microliter). Platelets are specialized blood cells that help prevent and stop bleeding by participating in clotting. Normal platelet range for a person without ITP is 150,000 to 400,000 platelets per microliter. AMG 531 is designed as a new approach for the treatment of ITP and other platelet deficiencies, directly increasing platelet production to overcome the destruction of platelets by the immune system.Traditional therapies for ITP have focused decreasing platelet destruction by suppressing the immune system, beginning with the use of steroids, followed by the surgical removal of the spleen and more intensive immunosuppression.
These treatments have potentially serious side effects. For patients with ITP who do not respond to these treatments, there are effective treatment options, James George, MD, professor of medicine, said at the University of Oklahoma Center for Health Sciences, Oklahoma City. The long-term study results show that AMG 531 administered weekly individual dose led to a durable platelet response.If approved, AMG 531 may be an Canadian monaslim amex no prescription needed online 56Pages: [1] 2 3 4 5 6 7